Algorithm-Enabled Low-Dose Micro-CT Imaging

Low-Dose Micro-CT Imaging for Vascular Segmentation and Analysis Using Sparse-View Acquisitions

The aim of this study is to investigate whether reliable and accurate 3D geometrical models of the murine aortic arch can be constructed from sparse-view data in vivo micro-CT acquisitions. This would considerably reduce acquisition time and X-ray dose. In vivo contrast-enhanced micro-CT datasets were reconstructed using a conventional filtered back projection algorithm (FDK), the image space r...

Low-dose 4D cardiac imaging in small animals using dual source micro-CT.

Micro-CT is widely used in preclinical studies, generating substantial interest in extending its capabilities in functional imaging applications such as blood perfusion and cardiac function. However, imaging cardiac structure and function in mice is challenging due to their small size and rapid heart rate. To overcome these challenges, we propose and compare improvements on two strategies for c...

Estimation of fetal absorbed dose from low-dose attenuation-correction CT in PET / CT imaging by using the Body Builder Phantom

One of the methods of studying the physiology and metabolism of important tissues such as the heart, brain and cancer tumors is the use of PET/CT System. A small number of patients are pregnant women who undergo a PET/CT scan due to lack of knowledge about pregnancy or due to dire clinical need. The final dose received by the fetus is based on three factors: the absorbed dose of the fetal tissu...

Temporal and spectral imaging with micro-CT.

PURPOSE Micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary disease, but further development is needed to improve spatial resolution, temporal resolution, and material contrast. We present a technique for visualizing the changing distribution of iodine in the cardiac cycle with dual source micro-CT. METHODS The approach entails a retrospectively gated du...

Correlating Micro-CT Imaging with Quantitative Histology